DMT stands for N, N-Dimethyltryptamine. It is a powerful serotonergic drug that has actions on humans’ brain, which can induce a rapid and intense psychedelic feeling, often referred as a “DMT-induced trip”. DMT is the term used to describe the DMT experience is typically characterized by hallucinations of the visual, often involving powerful entities, and often accompanied by more profound significance. This experience that is meaningful can be described as a “DMT breakthrough”. When it’s used as a leisure medication, DMT can be smoked, snorted, or given in crystal form.
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The DMT molecule has a structural similarity to other psychedelic tryptamines such as 5-MeO DMT, 4-AcO DMT and psilocybin. These allow it to bind with serotonin receptors, causing psychedelic effects.
DMT can be found naturally in a myriad of plants. It has been used for centuries as a psychoactive ingredient in ayahuasca, a rich hallucinogenic beverage that is considered to be a key component of shamanic traditions in the Upper and Lower Amazon.
There is currently no evidence for the endogenous DMT production in humans, and specifically, whether DMT is produced in the brain.
What does DMT have in common and what can it be used?
DMT comes in many formsthat are suitable for different methods of consumption and can alter the duration and duration of your experience. Pure DMT is an crystalline white powder or solid, however it is more commonly found as a yellow-pink substance or powder. It can also be found in herbal mixes called ‘changa’.
Smoked (DMT): DMT powder can be smoked through the form of a bong or pipe or vaporized with the use of vape pen. Freebase DMT is usually linked to smoking.
Smoked (Changa): Changa is an herb mix that contains both an extract containing DMT and a monoamine oxide inhibitor (MAOI)-containing extracts from plants. This combination of DMT and MAOI are based on the chemical principles that ayahuasca is based on in which the addition MAOI prolongs the experience. Changa can be smoked by smoking it in a joint, pipe or bong, and vaporized by a vape pen.
The injection: DMT should be injected in salt (DMT fumarate).
Ingestion/Orally: Consumed orally as Ayahuasca.
While DMT occurs naturally on the plant, it can also be synthesized chemically, resulting in DMT in its base or salt form. The term ‘freebase DMT is the term used to refer to DMT in its alkaloidal state and is not soluble within water, whereas “DMT fumarate” refers to the salt form , and is water soluble.
How does DMT work as a drug in the body and brain?
DMT is a psychedelic tryptamine. It’s an indole alkaloid that has the same chemical structure as serotonin, a neurotransmitter. This similarity in structure between DMT and serotonin permits it to be bound to serotonin receptors. Specifically, DMT acts as an agonist of the 5-HT2A receptor. As such, it binds and stimulates an response. It is thought that 5-HT2A receptor agonism plays an essential role when it comes to hallucinogenic results of DMT. The 5-HT2A receptor is linked with several other classical psychedelics such as psilocybin, a.k.a LSD and as such, these psychedelics are frequently described as serotonergic psychodrugs.
What are the consequences of DMT?
Psychological effects
DMT is rapidly acting and effects usually appear around 2-5 minutes after consumption and last around 15-20 minutes. Despite its short-lived effects, DMT is known as one of the strongest psychoactive drugs. The effects that people experience from DMT can be profound but will vary with dosage. The most notable are:
The intense visual changes can trigger hallucinations, specifically colourful and geometric forms
Mystical or profound spiritual experiences
The mood can change with emotions, including feelings of joy, calm, fear and anxiety
Perceived encounters with other beings, often described as elf-like.
Altered sense of time and location
Feelings of depersonalisation or other out of body experiences
Possible auditory hallucinations
Recalling powerful memories
Effects of physiology
DMT is associated with low toxicity and can be easily utilized through the body. But, there are physiological effects and potential risks to consider. These include elevated blood pressure and increased blood pressure, which are particularly harmful for those with heart diseases. A diminished cognitive and motor function can pose a safety risk , and provides a reason for DMT to be consumed in a safe setting, with a sober and sane sitter. Be aware that in high doses, there are some reports of respiratory effects, seizures and Comas.
Does DMT have any medical applications?
DMT and its consumption through ayahuasca, has a long history of medicinal use in the traditional way for various indigenous tribes in the Lower and Upper Amazon. The therapeutic potential of ayahuasca as a tool for therapy for psychotherapy has attracted a lot of attention in the field of clinical studies. Numerous clinical trials have revealed positive results in treating addiction and depression.
The growing mainstream appreciation for the healing potential of ayahuasca (DMT-containing brew) as well as other psychedelics of the past has spurred increased interest from scientists regarding whether DMT has therapeutic potential. The results of scientific studies have shown the similarities to DMT and psilocybin, whereby DMT is able to produce a comparable mystical experience to that of Psilocybin. It is thought that psilocybin influences brain activity, allowing for the brain’s reset. Therefore, recent evidence that DMT induces changes in the brain activity of humans may be beneficial. This suggests that DMT may have a similar effectiveness to psilocybin for treating mental disorders like depression and anxiety.
Are DMT risk-free? What is the best way to make sure the risks can be avoided or reduced?
DMT is a potent psychedelic drug . However, as in all other drugs it is essential that people are aware for the psychological and physiological dangers associated with the use of DMT.
DMT creates a potent psychedelic experience consisting of intense visual alterations and hallucinations along with changes in mood and mood. The intensity of the trip can be emotionally challenging for some people, inducing states of panic, anxiety and paranoia. For certain people, DMT can trigger an experience of a heightened state or depersonalisation, which could be overwhelming. Similar to all psychedelics, the psychological risk can be minimised by ‘set and setting’, making sure that your mind is secure and well-prepared as well as that the environment is secure and encouraging. A sober-sitting sitter is a crucial safety precaution to prevent the psychological damage.
Find out more about DMT harm reduction in the harm reduction guidelines section.
Are there medical conditions that can make DMT more hazardous?
Similar to other psychedelics, having a history of mental illness (such as schizophrenia, psychosis and bipolar disorder) can increase the risk of having a negative experience, and there is a chance that DMT can worsen these conditions. But, there is an incomplete understanding of the dangers associated with the use of psychedelics for patients with mental health disorders.
It is important to know that DMT can affect the serotonin-producing system and therefore should not be consumed in conjunction together with other substances that affect the system of serotonin. It could result in a potentially life-threatening condition called serotonin syndrome. This can be caused by antidepressants, as well as selective serotonin reuptake inhibitors (SSRIs).
The following prescription drugs carry an associated risk:
SSRIs
Antipsychotics (although some will hinder the action of DMT)
Opioids, specifically tramadol
Antihypertensives
Central nervous system depressants
Vasodilators
Can DMT be mixed with other drugs?
DMT is not recommended to mix alongside alcohol, or any other substances and a thorough understanding of its effects and the mechanism could provide insights into the dangers with mixing it with other substances.
Important drug combinations to avoid The following list of key drug combinations to avoid is provided:
DMT shouldn’t be mixed with tramadol due to the higher risk of seizures
DMT shouldn’t be mixed in with other stimulants such as cocaine and amphetamines.
DMT shouldn’t be mixed with cannabis.
DMT is a potent psychoactive and mixing it into other hallucinogens can increase the chance of making the experience more intense
DMT is not recommended to be mixed with any recreationally used prescription drugs that are known to possibly cause interactions with DMT. This includes all of the ones that are listed above.
Is DMT addictive?
DMT and other classical psychedelics, is not addictive. However, tolerance can build when using it regularly, meaning you need to use a higher dose to get the same result.
DMT harm reduction advice
DMT is a powerful psychoactive drug that can trigger an intense and intense hallucinogenic feeling. A well-informed harm reduction strategy will help reduce some of the potential risks.
Being well-educated and prepared
It is crucial to take the time to fully understand the potential health risks as well as drug interactions that can be triggered by DMT. It is essential to ensure the proper way of taking it and the right dosage is employed along with a suitable dose. The extremely strong nature of DMT means that sufficient preparation is done. This means being aware of the psychological and physical consequences that DMT can trigger. Also, preparation is linked to the person’s mental set.
Set and setting
“Set” refers the person’s mind-set including their mood, thoughts and expectations. This could have a major influence on the enjoyment of the journey and, therefore, it is recommended to ensure that DMT should only be consumed at times when the user is in a positive and stable mental state. ‘Setting’ refers to the environment and social situation that the drug is consumed. DMT should be taken in a tranquil and safe environment, due to the intensity of the drug and the possibility of motor impairments.
Sitter
The presence of a sober sitter is especially suggested when using DMT. The sitter is able to provide reassurance and assistance throughout and after the journey. The stability of the person who is seated is vital and will provide a sense of clarity and direction through any confusing or overwhelming experiences.
DMT myths and misunderstandings
Do human brains produce DMT?
There is a great deal of debate over whether DMT is produced by the human brain. Much of the discussion has been focused around the pineal gland. It’s a small organ located in the central part of the brain, which had been popularised by many as the main source of DMT. However, the evidence supporting this theory is not a lot.
A trace amount of DMT has been found in human blood and urine and urine, which support the theory of the endogenous release of DMT in the human body. Although a recent study detected DMT inside the pineal glands that is found in rodents, there is no evidence that this is the case within the pineal gland of our brain. The study that followed confirmed that DMT is still produced in the brains of rats following the detaching the pineal area, increasing the debate over whether the pineal gland is the principal supply of DMT. Understanding endogenous DMT creation in humans and its possible roles in physiology remains an understudied area and extensive further studies are needed.
Are DMT and 5-MeO-DMT the same?
5-MeO-DMT stands for 5-Methoxy-N,N-Dimethyltryptamine. While they may appear like each other, and share similar chemical structures, they induce different experiences and should not be confused.